| Date | Opponent | Rank | Win % | Score |
|---|---|---|---|---|
| 2021-09-04 | Georgia | 5 | 60.02 | 3 - 10 |
| 2021-09-11 | S Carolina St | 205 | 99.76 | 49 - 3 |
| 2021-09-18 | Georgia Tech | 99 | 95.96 | 14 - 8 |
| 2021-09-25 | @ NC State | 50 | 80.05 | 21 - 27 |
| 2021-10-02 | Boston College | 58 | 85.45 | 19 - 13 |
| 2021-10-15 | @ Syracuse | 78 | 82.56 | 17 - 14 |
| 2021-10-23 | @ Pittsburgh | 16 | 47.73 | 17 - 27 |
| 2021-10-30 | Florida St | 53 | 71.70 | 30 - 20 |
| 2021-11-06 | @ Louisville | 56 | 55.91 | 30 - 24 |
| 2021-11-13 | Connecticut | 198 | 98.26 | 44 - 7 |
| 2021-11-20 | Wake Forest | 21 | 53.59 | 48 - 27 |
| 2021-11-27 | @ South Carolina | 70 | 71.23 | 0 - 0 |