| Date | Opponent | Rank | Win % | Score |
|---|---|---|---|---|
| 2021-09-05 | Notre Dame | 9 | 9.67 | 38 - 41 |
| 2021-09-11 | Jacksonville St | 149 | 85.82 | 17 - 20 |
| 2021-09-18 | @ Wake Forest | 58 | 23.88 | 14 - 35 |
| 2021-09-25 | Louisville | 40 | 27.83 | 23 - 31 |
| 2021-10-02 | Syracuse | 80 | 43.46 | 33 - 30 |
| 2021-10-09 | @ North Carolina | 20 | 12.33 | 35 - 25 |
| 2021-10-23 | Massachusetts | 210 | 95.10 | 59 - 3 |
| 2021-10-30 | @ Clemson | 25 | 28.30 | 20 - 30 |
| 2021-11-06 | NC State | 19 | 37.22 | 14 - 28 |
| 2021-11-13 | Miami FL | 35 | 44.72 | 31 - 28 |
| 2021-11-20 | @ Boston College | 68 | 47.60 | 26 - 23 |
| 2021-11-27 | @ Florida | 56 | 44.85 | 21 - 24 |