| Date | Opponent | Rank | Win % | Score |
|---|---|---|---|---|
| 2021-09-04 | Colgate | 231 | 99.08 | 51 - 0 |
| 2021-09-11 | @ Massachusetts | 211 | 96.52 | 45 - 28 |
| 2021-09-18 | @ Temple | 126 | 76.55 | 28 - 3 |
| 2021-09-25 | Missouri | 52 | 52.33 | 41 - 34 |
| 2021-10-02 | @ Clemson | 7 | 14.55 | 13 - 19 |
| 2021-10-16 | NC State | 51 | 55.88 | 7 - 33 |
| 2021-10-23 | @ Louisville | 52 | 35.01 | 14 - 28 |
| 2021-10-30 | @ Syracuse | 60 | 32.85 | 6 - 21 |
| 2021-11-05 | Virginia Tech | 65 | 41.91 | 17 - 3 |
| 2021-11-13 | @ Georgia Tech | 66 | 37.91 | 41 - 30 |
| 2021-11-20 | Florida St | 58 | 52.40 | 23 - 26 |
| 2021-11-27 | Wake Forest | 37 | 40.88 | 10 - 41 |