| Date | Opponent | Rank | Win % | Score |
|---|---|---|---|---|
| 2021-08-28 | E Illinois | 214 | 85.36 | 26 - 21 |
| 2021-09-11 | @ Northwestern | 27 | 3.34 | 6 - 24 |
| 2021-09-18 | @ E Kentucky | 169 | 54.06 | 23 - 21 |
| 2021-09-25 | S Dakota St | 83 | 20.08 | 0 - 44 |
| 2021-10-02 | @ South Dakota | 128 | 26.87 | 10 - 38 |
| 2021-10-09 | W Illinois | 166 | 48.70 | 37 - 27 |
| 2021-10-16 | @ Missouri St | 131 | 25.81 | 7 - 37 |
| 2021-10-23 | Youngstown St | 165 | 46.04 | 28 - 17 |
| 2021-10-30 | @ N Dakota St | 59 | 5.87 | 2 - 44 |
| 2021-11-13 | S Illinois | 94 | 17.24 | 21 - 47 |
| 2021-11-20 | @ Illinois St | 144 | 17.99 | 15 - 10 |