| Date | Opponent | Rank | Win % | Score |
|---|---|---|---|---|
| 2021-09-04 | Southern Miss | 124 | 47.63 | 31 - 7 |
| 2021-09-11 | @ Bowling Green | 210 | 81.69 | 22 - 19 |
| 2021-09-18 | Alcorn St | 188 | 80.71 | 28 - 21 |
| 2021-10-02 | Louisiana | 60 | 15.67 | 18 - 20 |
| 2021-10-09 | @ Texas St | 171 | 61.36 | 31 - 33 |
| 2021-10-14 | Ga Southern | 108 | 41.03 | 41 - 14 |
| 2021-10-23 | @ ULM | 182 | 72.28 | 31 - 41 |
| 2021-10-30 | Arkansas St | 138 | 64.45 | 31 - 13 |
| 2021-11-06 | @ Troy | 103 | 35.74 | 24 - 31 |
| 2021-11-13 | @ Appalachian St | 34 | 10.50 | 7 - 31 |
| 2021-11-20 | @ Tennessee | 28 | 9.64 | 14 - 60 |
| 2021-11-26 | Coastal Car | 60 | 21.36 | 21 - 27 |