| Date | Opponent | Rank | Win % | Score |
|---|---|---|---|---|
| 2021-09-04 | C Michigan | 103 | 82.53 | 34 - 24 |
| 2021-09-11 | @ Kentucky | 36 | 39.68 | 28 - 35 |
| 2021-09-18 | SE Missouri St | 182 | 96.24 | 59 - 28 |
| 2021-09-25 | @ Boston College | 65 | 47.67 | 34 - 41 |
| 2021-10-02 | Tennessee | 59 | 57.30 | 24 - 62 |
| 2021-10-09 | North Texas | 157 | 85.75 | 48 - 35 |
| 2021-10-16 | Texas A&M | 12 | 16.58 | 14 - 35 |
| 2021-10-30 | @ Vanderbilt | 175 | 75.66 | 37 - 28 |
| 2021-11-06 | @ Georgia | 1 | 1.40 | 6 - 43 |
| 2021-11-13 | South Carolina | 78 | 42.90 | 31 - 28 |
| 2021-11-20 | Florida | 51 | 33.35 | 24 - 23 |
| 2021-11-26 | @ Arkansas | 26 | 16.41 | 17 - 34 |