| Date | Opponent | Rank | Win % | Score |
|---|---|---|---|---|
| 2021-09-04 | Alabama | 1 | 3.93 | 13 - 44 |
| 2021-09-11 | Appalachian St | 46 | 68.28 | 25 - 23 |
| 2021-09-18 | Michigan St | 50 | 67.82 | 17 - 38 |
| 2021-09-25 | Central Conn | 209 | 98.15 | 69 - 0 |
| 2021-09-30 | Virginia | 55 | 67.07 | 28 - 30 |
| 2021-10-16 | @ North Carolina | 35 | 40.35 | 42 - 45 |
| 2021-10-23 | NC State | 30 | 52.52 | 31 - 30 |
| 2021-10-30 | @ Pittsburgh | 6 | 17.73 | 38 - 34 |
| 2021-11-06 | Georgia Tech | 80 | 79.06 | 33 - 30 |
| 2021-11-13 | @ Florida St | 61 | 55.28 | 28 - 31 |
| 2021-11-20 | Virginia Tech | 63 | 66.33 | 38 - 26 |
| 2021-11-27 | @ Duke | 166 | 90.30 | 47 - 10 |