| Date | Opponent | Rank | Win % | Score |
|---|---|---|---|---|
| 2021-09-04 | Villanova | 141 | 10.02 | 3 - 47 |
| 2021-09-11 | @ Richmond | 160 | 7.08 | 3 - 31 |
| 2021-09-18 | Princeton | 163 | 12.22 | 0 - 32 |
| 2021-09-25 | @ Colgate | 239 | 33.02 | 3 - 30 |
| 2021-10-02 | Yale | 172 | 9.39 | 0 - 34 |
| 2021-10-09 | @ Penn | 218 | 16.97 | 0 - 20 |
| 2021-10-23 | @ Fordham | 161 | 5.96 | 28 - 35 |
| 2021-10-30 | Holy Cross | 152 | 8.46 | 12 - 31 |
| 2021-11-06 | @ Bucknell | 255 | 58.48 | 38 - 6 |
| 2021-11-13 | Georgetown | 246 | 61.45 | 23 - 9 |
| 2021-11-20 | Lafayette | 223 | 51.11 | 17 - 10 |